ReVISION

Congenital heart diseases (CHDs) affect approximately 1.4 million babies born each year. 1 in 4 of these require surgery or other interventions in the first year of life. When CHD impacts the right ventricle (RV), a detailed analysis of the ways RV mechanics have been altered is critical to establish the correct diagnosis and treatment plan. [1]

CHDs manifest themselves in many different, complex ways and can create a wide range of cardiac malformations. In many cases, characteristics of the RV have a pivotal impact on the disease presentation and progression. Depending on the specific type of CHD, the right ventricle could be exposed to severe pressure and/or volume overload (eg. intracardiac shunts) or, in certain cases (eg. complex malformations such as tetralogy of Fallot), the heart muscle architecture could also differ from the typical structure. And, this effect may become more prominent based on the altered loading conditions of the RV. Sorting out the magnitude and clinical relevance of these different effects is difficult without a granular and quantified view of the RV.[2]

With appropriate care, over 97% of children with CHD are expected to reach adulthood.[3] As a result, CHD-related conditions can affect a person's health status across their lifespan and require extensive and specific cardiovascular care. In the US, critical congenital heart defect-associated hospitalizations had the highest mean and median costs ($79,011 and $29,886, respectively). Given the cost of the treatments, the high impact of successful treatments on patient's quality and length of life, and the complexity of the disease, particularly as it affects the RV, understanding the details of an individual patient's CHD is particularly important.[4]

Argus Cognitive has developed a system for a deeper analysis of RV 3D echocardiographic data. ReVISION is a unique solution that allows to separately quantify the three major functional components that contribute to total 3D right ventricle ejection fraction (RVEF): longitudinal shortening, radial shortening, and anteroposterior shortening.

ReVISION measures longitudinal, radial, and anteroposterior ejection fraction, and quantifies 3D global circumferential, longitudinal, and area strains as well. Previous studies have shown the usefulness and importance of accurately measuring the altered RV mechanics in different CHDs.[5,6]

ReVISION offers a solution to comprehensively quantify the different components contributing to the global RV function, and provide critical information which is not available using conventional instruments to help improve our understanding of the mechanisms leading to RV failure in CHD patients.

To try ReVISION for yourself, click to see how ReVISION provides a comprehensive and quantified view of RV function.

Pricing Plans

Basic Research

$700 / month

or

$7000 / year

User accounts that can run analyses and export data: up to 3
  • Supports 1 project with a single combined dataset

  • Supports export of analysis results in table format

  • ReVISION features enabled: all

  • Included raw 3D echo DICOM uploads per month: 12 Each additional raw 3D echo DICOM upload: $30 USD

  • Delivery: software as a service via revision.arguscognitive.com

Clinical Trial

$4000 / month

or

$40000 / year

User accounts that can run analyses and export data: unlimited
  • Supports 1 project with a single combined dataset

  • Supports export of analysis results in table format

  • ReVISION features enabled: all

  • Included raw 3D echo DICOM uploads per month: 100 Each additional raw 3D echo DICOM upload: $30 USD

  • Delivery: software as a service via revision.arguscognitive.com

References

[1] van der Linde, Denise et al. “Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis.” Journal of the American College of Cardiology vol. 58,21 (2011): 2241-7. doi:10.1016/j.jacc.2011.08.025

[2] Kovács, A., Lakatos, B., Tokodi, M., & Merkely, B. (2019). Right ventricular mechanical pattern in health and disease: beyond longitudinal shortening. Heart failure reviews, 24(4), 511-520. https://doi.org/10.1007/s10741-019-09778-1

[3] Mandalenakis, Zacharias et al. “Survival in Children With Congenital Heart Disease: Have We Reached a Peak at 97%?.” Journal of the American Heart Association vol. 9,22 (2020): e017704. doi:10.1161/JAHA.120.017704

[4] Arth, A. C., Tinker, S. C., Simeone, R. M., Ailes, E. C., Cragan, J. D., & Grosse, S. D. (2017). Inpatient Hospitalization Costs Associated with Birth Defects Among Persons of All Ages - United States, 2013. MMWR. Morbidity and mortality weekly report, 66(2), 41-46. https://doi.org/10.15585/mmwr.mm6602a1

[5] Bidviene, J., Muraru, D., Kovacs, A., Lakatos, B., Ereminiene, E., Liptai, C., Vaskelyte, J. J., Zaliunas, R., Surkova, E., & Badano, L. P. (2021). Global and regional right ventricular mechanics in repaired tetralogy of Fallot with chronic severe pulmonary regurgitation: a three-dimensional echocardiography study. Cardiovascular ultrasound, 19(1), 28. https://doi.org/10.1186/s12947-021-00260-3

[6] Surkova, E., Kovács, A., Lakatos, B. K., Tokodi, M., Fábián, A., West, C., Senior, R., & Li, W. (2021). Contraction patterns of the systemic right ventricle: a three-dimensional echocardiography study. European heart journal. Cardiovascular Imaging, jeab272. Advance online publication. https://doi.org/10.1093/ehjci/jeab272